The Cyclonic Disruptor was the titular 'ultimate weapon in the episode The Ultimate Weapon.
V.E.N.O.M. perfected a device capable of interfering with M.A.S.K.'s technology, particularly their vehicle's operating systems, making them go haywire. The Cyclonic Disruptor appeared to be the size of a typewriter and was installed inside Switchblade's cockpit.
V.E.N.O.M. used the Cyclonic Disruptor during a series of raids on domeshaped buildings. The first attack, on a large cinema showing the premiere of the 'space wars' movie titled 2020 was just to get M.A.S.K.'s attention.
Subsequently, V.E.N.O.M. let information leak out that their next target was The Mackenzie Observatory. This was done to lure M.A.S.K. into a trap and test the Cyclonic Disruptor on them. Indeed, none of the M.A.S.K. vehicle's weapons worked the way they should and the flying vehicles had trouble remaining in the air, leading to Condor crashing into Shark. Even T-Bob, who was visiting the observatory with Scott Trakker got his circuits scrambled and began to go haywire.
Switchblade got away with the McKenzie telescope, but soon dumped it on a backroad. The theft had merely been a dress rehearsal for a more important theft: the Phelps Breeder Reactor which had just received a big shipment of plutonium.
By this time, Alex Sector had developed a divice to neutralize the Disruptor's effect and he and Buddy Hawks spent all night installing them in each of M.A.S.K.'s vehicles. Using T-Bob as an indicator, each M.A.S.K. agent activated their neutarlizers during V.E.N.O.M.'s attack on the Breeder Reactor, but Matt Trakker instructed them to still act as if they were beint disrupted to trick V.E.N.O.M. When he realized this, Miles Mayhem simply increased the power on his disruptor, thereby neutralizing Sector's neutralizers.
However, the Disruptor did not appear to work on M.A.S.K.'s masks such as Sector's Jackrabbit. Also, Brad Turner managed to fool Mayhem with a holographic projection of multiple M.A.S.K. vehicles projected by his Hocus Pocus mask while he himself remained just out of range of the disruptor flying in Condor.
Mayhem ordered a retreat, leaving a time bomb behind at the Reactor. Sector saved the day by using a rocket pack from Jackrabbit to fly the device high enough into the air for it to do no damage when exploding. Defeated, V.E.N.O.M. made no further use of the Cyclonic Disruptor.